DEAL: For $25 - Add A Second Phone Number To Your Smartphone for life! Use promo code SLASHDOT25. Also, Slashdot's Facebook page has a chat bot now. Message it for stories and more. Check out the new SourceForge HTML5 internet speed test! ×
Biotech

Researchers Discover A Surprising New Role for Lungs: Making Blood (ucsf.edu) 55

schwit1 quotes ScienceAlert: In experiments involving mice, the team found that lungs produce more than 10 million platelets (tiny blood cells) per hour, equating to the majority of platelets in the animals' circulation. This goes against the decades-long assumption that bone marrow produces all of our blood components. Researchers from the University of California, San Francisco also discovered a previously unknown pool of blood stem cells that makes this happen inside the lung tissue -- cells that were incorrectly assumed to mainly reside in bone marrow. "This finding definitely suggests a more sophisticated view of the lungs -- that they're not just for respiration, but also a key partner in formation of crucial aspects of the blood," says one of the researchers, Mark R. Looney.
The platelet-producing cells actually migrate from the bone marrow to the lungs.
Biotech

Theranos To Investors: Please Don't Sue! Here, Have Some More Shares (siliconbeat.com) 85

Theranos "plans to give additional shares to investors who pledge not to sue," reports the Wall Street Journal. An anonymous reader quotes Silicon Beat: The deal, which hasn't been disclosed publicly, was approved by the Palo Alto-based company's board last month, The Wall Street Journal reported, citing anonymous "people familiar with the matter." They said most investors have tentatively agreed to the deal. Those extra shares are coming from none other than founder and CEO Elizabeth Holmes' personal cache, the Journal reported. That means the beleaguered founder, who has remained stubbornly at the helm of her struggling startup even though federal regulators have barred her from running a medical lab for two years, would give up her majority ownership in the company.
Beer

Alcohol Is Good for Your Heart -- Most of the Time (time.com) 122

Alcohol, in moderation, has a reputation for being healthy for the heart. Drinking about a glass of wine for women per day, and two glasses for men, is linked to a lower risk of heart attack, stroke and death from heart disease. From a report on Time: A new study of nearly two million people published in The BMJ adds more evidence that moderate amounts of alcohol appear to be healthy for most heart conditions -- but not all of them. The researchers analyzed the link between alcohol consumption and 12 different heart ailments in a large group of U.K. adults. None of the people in the study had cardiovascular disease when the study started. People who did not drink had an increased risk for eight of the heart ailments, ranging from 12 percent to 56 percent, compared to people who drank in moderation. These eight conditions include the most common heart events, such as heart attack, stroke and sudden heart-related death.
Medicine

Molecule Kills Elderly Cells, Reduces Signs of Aging In Mice (sciencemag.org) 127

An anonymous reader shares an excerpt from a Science Magazine report: Even if you aren't elderly, your body is home to agents of senility -- frail and damaged cells that age us and promote disease. Now, researchers have developed a molecule that selectively destroys these so-called senescent cells. The compound makes old mice act and appear more youthful, providing hope that it may do the same for us. As we get older, senescent cells build up in our tissues, where researchers think they contribute to illnesses such as heart disease, arthritis, and diabetes. In the past, scientists have genetically modified mice to dispatch their senescent cells, allowing the rodents to live longer and reducing plaque buildup in their arteries. Such genetic alterations aren't practical for people, but researchers have reported at least seven compounds, known as senolytics, that kill senescent cells. A clinical trial is testing two of the drugs in patients with kidney disease, and other trials are in the works. However, current senolytic compounds, many of which are cancer drugs, come with downsides. They can kill healthy cells or trigger side effects such as a drop in the number of platelets, the cellular chunks that help our blood clot. Cell biologist Peter de Keizer of Erasmus University Medical Center in Rotterdam, the Netherlands, and colleagues were investigating how senescent cells stay alive when they uncovered a different strategy for attacking them. Senescent cells carry the type of DNA damage that should spur a protective protein, called p53, to put them down. Instead, the researchers found that a different protein, FOXO4, latches onto p53 and prevents it from doing its duty. To counteract this effect, De Keizer and colleagues designed a molecule, known as a peptide, that carries a shortened version of the segment of FOXO4 that attaches to p53. In a petri dish, this peptide prevented FOXO4 and p53 from hooking up, prompting senescent cells to commit suicide. But it spared healthy cells. The researchers then injected the molecule into mutant mice that age rapidly. These rodents live about half as long as normal mice, and when they are only a few months old, their fur starts to fall out, their kidneys begin to falter, and they become sluggish. However, the peptide boosted the density of their fur, reversed the kidney damage, and increased the amount of time they could scurry in a running wheel, the scientists report online today in Cell. When the researchers tested the molecule in normal, elderly mice, they saw a similar picture: In addition to helping their kidneys and fur, the molecule also increased their willingness to explore their surroundings.
Software

Researchers Develop App That Accurately Determines Sperm Quality (scientificamerican.com) 101

New submitter omaha393 writes: A team of researchers at Harvard Medical School have developed a point-of-care microfluidic detector capable of determining sperm quality using the simple device and a standard smartphone. Typical male fertility screens require a team of trained laboratory professionals and a screening process taking days to weeks and incurring high costs. The alternative home sperm measuring kits rely on chemical probes and only give measurements of quantity, not quality.The new method offers an easier, cheaper approach, with processing time taking about 5 seconds with no sample processing or wash steps required. The team found their device meets WHO guidelines with 98% accuracy of sperm quality measurements and is comparable to clinical results. The new device uses 35 microliters of sample to accurately measure both concentration and motility at a manufacturing cost of less than $5 per device. The device must still undergo FDA evaluations before being available to consumers, and the technology has yet to be named. The results of the study were published in the journal Science Translational Medicine. Further reading: NPR, Ars Technica, Scientific American
Medicine

Most Teens Who Abuse Opioids First Got Them From a Doctor (livescience.com) 181

An anonymous reader quotes a report from Live Science: Most American teenagers who abuse opioid drugs first received the drugs from a doctor, a new study finds. Researchers looked at trends in the use of prescription opioids among U.S. adolescents from 1976 to 2015. They found a strong correlation between teens' taking the drugs for medical reasons and then later taking them for "non-medical" reasons, or in other words, abusing them, according to the study published today (March 20) in the journal Pediatrics. In 2015, the the most recent year of the study, 8 percent of adolescents reported abusing prescription opioids, and the majority of them had been prescribed opioids previously, the researchers found. The U.S. consumes about 80 percent of the world's prescription opioid supply. There has been consistent growth in the number of prescriptions written for opioids in the U.S., rising from 76 million prescriptions in 1991 to 207 million in 2013, according to the National Institute on Drug Abuse. However, the new study revealed that among teens, both medical and non-medical use of opioid medications has declined in recent years, starting in 2013. The decline may be due to careful prescribing practices, Sean McCabe, a research professor at the University of Michigan, said. There are several medical procedures that teens may undergo for which opioids are recommended for pain management. But doctors can be careful about the amount of these drugs they prescribe, and limit refills. Parents can make sure that any leftover pills are discarded. Another report was published today in the journal Pediatrics that analyzed data from the National Poison Data System. It found that of all 188,468 prescription opioid exposures reported for youth under 20 years old between 2000 and 2015, nearly all the exposures occurred at a home and were most common among children under 5, accounting for six of every 10 cases. According to NPR, those children were able to get their hands on the medication because it was improperly stored or was in a purse.
Space

Miniature Lab Begins Science Experiments in Outer Space (reuters.com) 27

An anonymous reader shares a Reuters report: Orbiting the earth at more than 500 kilometers (300 miles), a tiny satellite with a laboratory shrunk to the size of a tissue box is helping scientists carry out experiments that take gravity out of the equation. The technology was launched into space last month by SpacePharma, a Swiss-Israeli company, which on Thursday announced that its first experiments have been completed successfully. In space, with hardly any interference from earth's gravity, cells and molecules behave differently, helping researchers make discoveries in fields from medicine to agriculture. Nestle turned to zero gravity -- or what scientists refer to as microgravity -- to perfect the foam in its chocolate mousse and coffee, while drugmakers like Eli Lilly have used it to improve drug designs.
Medicine

Unproven Stem Cell Treatments Blind 3 Women (npr.org) 108

An anonymous reader quotes a report from NPR: Scientists have long hoped that stem cells might have the power to treat diseases. But it's always been clear that they could be dangerous too, especially if they're not used carefully. Now a pair of papers published Wednesday in the New England Journal of Medicine is underscoring both the promise and the peril of using stem cells for therapy. In one report, researchers document the cases of three elderly women who were blinded after getting stem cells derived from fat tissue at a for-profit clinic in Florida. The treatment was marketed as a treatment for macular degeneration, the most common cause of blindness among the elderly. Each woman got cells injected into both eyes. In a second report, a patient suffering from the same condition had a halt in the inexorable loss of vision patients usually experience, which may or may not have been related to the treatment. That patient got a different kind of stem cell derived from skin cells as part of a carefully designed Japanese study. The Japanese case marks the first time anyone has given induced pluripotent stem (iPS) cells to a patient to treat any condition. The report about the three women in their 70s and 80s who were blinded in Florida is renewing calls for the Food and Drug Administration to crack down on the hundreds of clinics that are selling unproven stem cell treatments for a wide variety of medical conditions, including arthritis, autism and stroke.
Medicine

Researchers Suggest Using Blockchain For Electronic Health Records (hbr.org) 70

The CIO at a Boston teaching hospital and two MIT researchers write in the Harvard Business Review that blockchain "has the potential to enable secure lifetime medical record sharing across providers," calling it "a different construct, providing a universal set of tools for cryptographic assurance of data integrity, standardized auditing, and formalized 'contracts' for data access." An anonymous reader quotes their report: A vexing problem facing health care systems throughout the world is how to share more medical data with more stakeholders for more purposes, all while ensuring data integrity and protecting patient privacy... Today humans manually attempt to reconcile medical data among clinics, hospitals, labs, pharmacies, and insurance companies. It does not work well because there is no single list of all the places data can be found or the order in which it was entered...

Imagine that every electronic health record (EHR) sent updates about medications, problems, and allergy lists to an open-source, community-wide trusted ledger, so additions and subtractions to the medical record were well understood and auditable across organizations. Instead of just displaying data from a single database, the EHR could display data from every database referenced in the ledger. The end result would be perfectly reconciled community-wide information about you, with guaranteed integrity from the point of data generation to the point of use, without manual human intervention.

Medicine

Scientists Have Found a Way To Rapidly Thaw Cryopreserved Tissue Without Damage (sciencealert.com) 94

schwit1 quotes a report from ScienceAlert: Researchers have developed a technique that allows them to rapidly thaw cryopreserved human and pig samples without damaging the tissue -- a development that could help get rid of organ transplant waiting lists. Cryopreservation is the ability to preserve tissues at liquid nitrogen temperatures for long periods of time and bring them back without damage, and it's something scientists have been dreaming about achieving with large tissue samples and organs for decades. Instead of using convection, the team used nanoparticles to heat tissues at the same rate all at once, which means ice crystals can't form, so they don't get damaged. To do this, the researchers mixed silica-coated iron oxide nanoparticles into a solution and generated uniform heat by applying an external magnetic field. They then warmed up several human and pig tissue samples ranging between 1 and 50 mL, using either their new nanowarming technique and traditional slow warming over ice. Each time, the tissues warmed up with nanoparticles displayed no signs of harm, unlike the control samples. Afterwards, they were able to successfully wash the nanoparticles away from the sample after thawing. The team also tested out the heating in an 80 mL system -- without tissue this time -- and showed that it achieved the same critical warming rates as in the smaller sample sizes, suggesting that the technique is scalable. You can view a video of tissue being thawed out in less than a minute here. The research has been published in Science Translational Medicine.
Medicine

New Scientific Test Finds Up To 75 Liters of Urine In Public Pools (theguardian.com) 215

Scientists have developed a test designed to estimate how much urine has been covertly added to a large volume of water. "The test works by measuring the concentration of an artificial sweetener, acesulfame potassium (ACE), that is commonly found in processed food and passed through the body unaltered," reports The Guardian. The findings are published in the American Chemical Society journal. From the report: After tracking the levels of the sweetener in two public pools in Canada over a three-week period they calculated that swimmers had released 75 liters of urine -- enough to fill a medium-sized dustbin -- into a large pool (about 830,000 liters, one-third the size of an Olympic pool) and 30 liters into a second pool, around half the size of the first. Although the researchers were unable to confirm exactly what fraction of visitors were choosing to quietly relieve themselves in the water rather than making the shivery trip to the changing rooms, the results suggest that the urine content was being topped up several times each day. The findings make for unwelcome reading, but swimmers might find some comfort in the measurements from eight hot tubs, which were found to have far higher urine levels. One hotel Jacuzzi had more than three times the concentration of sweetener than in the worst swimming pool. In total, the team sampled 31 different pools and tubs in two Canadian cities and found ACE to be present in 100% of the samples, with concentrations up to 570 times the background level in tap water samples. They used the average ACE concentration in Canadian urine to convert their measurements into approximate volumes of urine.
Earth

World's Only Sample of Metallic Hydrogen Has Been Lost (ibtimes.co.uk) 278

New submitter drunkdrone quotes a report from International Business Times: A piece of rare meta poised to revolutionize modern technology and take humans into deep space has been lost in a laboratory mishap. The first and only sample of metallic hydrogen ever created on earth was the rarest material on the planet when it was developed by Harvard scientists in January this year, and had been dubbed "the holy grail of high pressure physics." The metal was created by subjecting liquid hydrogen to pressures greater that those at the center of the Earth. At this point, the molecular hydrogen breaks down and becomes an atomic solid. Scientists theorized that metallic hydrogen -- when used as a superconductor -- could have a transformative effect on modern electronics and revolutionize medicine, energy and transportation, as well as herald in a new age of consumer gadgets. Sadly, an attempt to study the properties of metallic hydrogen appears to have ended in catastrophe after one of the two diamonds being used like a vice to hold the tiny sample was obliterated. The metal was being held between two diamonds at a pressure of around 71.7 million pounds per square inch -- more than a third greater than at the Earth's core. According to The Independent, one of these diamonds shattered while the sample was being measured with a laser, and the metal was lost in the process.
Medicine

Owning a Cat Does Not Lead To Mental Illness, Study Finds (theverge.com) 249

An anonymous reader quotes a report from The Verge: Cats host a parasite called Toxoplasma gondii that other research has linked to various mental illnesses. So, for some time, people have wondered whether cats are unsafe; for example, pregnant women are usually told to stay away from litter boxes. (They should still do this because transmission during pregnancy is very real.) In a study published in the journal Psychological Medicine, researchers looked at data that tracked 5,000 Brits born in the early '90s until they were 18. This included information about whether the kids grew up with cats, or whether there were cats around when the mother was pregnant. After the scientists controlled for factors like socioeconomic status, there was no link between developing psychosis and having owned a cat. The researchers suggest that previous studies that did show a link had relatively small sample sizes. In addition, many of these studies asked people whether they remembered having cats, which is not quite as accurate. That said, it's important to keep in mind that some mental disorders linked to the parasite -- like schizophrenia -- tend to be diagnosed fairly late in life, so only tracking until age 18 might limit the study.
Medicine

Studies Show Testosterone Offers Little Benefits To Aging Men (arstechnica.com) 138

An anonymous reader quotes a report from Ars Technica: In decades of research, scientists have found only one medical condition that's clearly and effectively treated with testosterone supplements: pathological hypogonadism -- that's low testosterone levels due to disease of the hypothalamus, pituitary gland, or testes. In a series of placebo-controlled, randomized trials, researchers tracked the effect of testosterone on the cognition, bone health, anemia, and cardiovascular health of 788 men for a year. All the men were aged 65 or older and had low testosterone levels that couldn't be explained by anything other than age. The results, reported Tuesday in JAMA and JAMA Internal Medicine, offer mixed results. Among the 493 in the trial who also had age-related memory declines, testosterone didn't have any effect on memory or cognitive abilities. In the study, 247 got testosterone and 246 got a placebo. But for cardiovascular health, there was an effect -- a bad one. Over the year, plaque buildup in the coronary artery -- which is a risk factor for heart disease -- increased in 73 men on testosterone compared with 65 on placebo. However, other studies have found mixed results on this. Longer, bigger trials will be needed to sort out the risks. In the anemia study, testosterone did seem to improve iron levels in men with mild anemia. The bone health study also showed that testosterone could improve bone density. However, it's unclear if those benefits outweigh the possible cardiovascular risks. And other drugs may be more effective at treating anemia and improving bone mass than testosterone.
IT

Computer Glasses Claim To Protect Eyesight Are Selling Like Hotcakes, But They Probably Aren't Useful (businessinsider.in) 118

People are increasingly concerned that bright light -- especially "blue light" from computer screens -- is causing harm, making it a potentially dangerous public health issue. Eyewear and screen protector companies have been selling products they say can protect people from these harms. But are they really making any difference? From a report: We do know that blue light at night can interfere with sleep, causing a host of negative effects. But the evidence that the amount of light screen expose us to during the day is harmful is not really there. Furthermore, many experts think these products are unnecessary and could perhaps do more harm than good. [...] The research that companies selling blue-blocking products cite falls into three categories: animal studies, in vitro studies of retinal cells exposed to light, and studies of people exposed to outdoor light. [...] "I think it's largely hype, not science," says Dr. Richard Rosen, Director of Retina Services at New York Eye and Ear Infirmary of Mount Sinai and Ophthalmology Research Director at Icahn School of Medicine. "They want to sell it; they know people get uncomfortable staring at screens all day, so they say, it's because of this [blue light issue]." The report cites insight from several other doctors as well studies to make a case for why these glasses aren't useful.
Biotech

SpaceX's Next Launch Carries Colonies Of A Drug-Resistant Superbug (businessinsider.com.au) 56

An anonymous reader quotes Business Insider: SpaceX is preparing to launch a lethal, antibiotic-resistant superbug into orbit...to live its days in the microgravity environment of the International Space Station. The idea is not to weaponize space with MRSA -- a bacterium that kills more Americans every year than HIV/AIDS, Parkinson's disease, emphysema, and homicide combined -- but to send its mutation rates into hyperdrive, allowing scientists to see the pathogen's next moves well before they appear on Earth. The NASA-funded study will see SpaceX's Falcon 9 rocket launch colonies of MRSA into space, to be cultivated in the US National Laboratory on the International Space Station.

"We will leverage the microgravity environment on the ISS to accelerate the Precision Medicine revolution here on Earth," lead researcher Anita Goel, CEO of biotech company Nanobiosym, told Yahoo News... "Our ability to anticipate drug-resistant mutations with Gene-RADAR will lead to next generation antibiotics that are more precisely tailored to stop the spread of the world's most dangerous pathogens," says Goel.

That launch was scheduled for today, but SpaceX postponed it to "take a closer look at positioning of the second stage engine nozzle." [UPDATE: The launch was completed successfully on Sunday.] Two more externally-mounted payloads will conduct other experiments, with one monitoring lightning strikes on earth and the other measuring chemicals in the earth's atmosphere. In addition, there's also 21 science experiments that were submitted by high school students

Meanwhile, Slashdot reader tomhath brings news that researchers have discovered the red berries of a U.S. weed can help fight superbugs. The researchers found "extracts from the Brazilian peppertree, which traditional healers in the Amazon have used for hundreds of years to treat skin and soft-tissue infections, have the power to stop methicillin-resistant MRSA infections in mice." One of the researchers said the extract "weakens the bacteria so the mouse's own defenses work better."
Medicine

B Vitamins Reduce Schizophrenia Symptoms, Study Finds (newsmax.com) 90

A new study published in the journal Psychological Medicine finds that high doses of B vitamins reduce the symptoms of schizophrenia. Researchers found that using B vitamins, including B6, inositol, and B12 as an adjunctive with antipsychotics significantly improved symptoms of the debilitating condition. Newsmax reports: For the new study, researchers identified 18 clinical trials with a combined total of 832 patients receiving antipsychotic treatment for schizophrenia. They found that B-vitamin interventions which used higher dosages or combined several vitamins were consistently effective for reducing psychiatric symptoms, whereas those which used lower doses were ineffective. The evidence also suggested that B-vitamin supplements were most beneficial when they were added to medicine regimens early after diagnosis.
Medicine

Ethicists Advise Caution In Applying CRISPR Gene Editing To Humans (washingtonpost.com) 159

New submitter Baron_Yam quotes a report from Washington Post (Warning: may be paywalled; alternate source): Ethicists have been working overtime to figure out how to handle CRISPR, the revolutionary gene-editing technique that could potentially prevent congenital diseases but could also be used for cosmetic enhancements and lead to permanent, heritable changes in the human species. The latest iteration of this ongoing CRISPR debate is a report published Tuesday by the National Academy of Sciences and the National Academy of Medicine. The report, a series of guidelines written by 22 experts from multiple countries and a variety of academic specialties, presents a kind of flashing red light for CRISPR. The report did not recommend an absolute prohibition of gene editing on the human "germline" if such interventions can be proved safe. This would involve genetic changes to eggs, sperm or embryos that would persist in an adult and could be inherited by future generations. For some ethicists, that represents a slippery slope. At the conclusion of a gene-editing summit in Washington at the National Academy of Sciences in December 2015, scientists said that although some basic research could proceed, it would be irresponsible to use genetically modified germline cells for the purpose of establishing a pregnancy. But the new report takes a slightly more permissive, forward-thinking position, saying that, if and when such interventions are proved safe -- which could be in the near future -- and if numerous criteria are met to ensure that such gene editing is regulated and limited, it could potentially be used to treat rare, serious diseases. "We say proceed with all due caution, but we don't prohibit germline, after considerable discussion and debate," said Richard Hynes, an MIT biologist and one of the leaders of the new study. "We're talking only about fixing diseases."
Medicine

New Study In Mice Shows That Increasing Serotonin Affects Motivation, But Only In Certain Circumstances (neurosciencenews.com) 47

New submitter baalcat quotes a report from Neuroscience News: A new study in mice shows that increasing serotonin, one of the major mediators of brain communication, affects motivation -- but only in certain circumstances. Furthermore, the study revealed that the short and long term effects of increased serotonin levels are opposed -- a completely unforeseen property of this neurotransmitter's functional system. A surprising behavioral effect, discovered in mice by neuroscientists at the Champalimaud Centre for the Unknown (CCU), in Lisbon, Portugal, strongly suggests that serotonin is involved in a biological mechanism which affects the animals' motivation. The study has now been published in the online open access journal eLife. Serotonin, one of the chemical "messengers," or neurotransmitters, in the brain, is used by neurons to communicate with each other. It plays an important role in the regulation of sleep, movement and other behaviors which are essential for animal survival. But for motivation in particular, it was unclear whether serotonin was involved. Using optogenetics, the team stimulated the release of serotonin from neurons in the raphe nuclei. They first induced "peaks" of serotonin by stimulating these neurons with pulses of light, lasting three seconds every ten seconds, over three five-minute time periods. The mice, placed in a box, were left free to explore their environment. In these conditions, their most frequent spontaneous behaviors are walking around, rearing, grooming, digging holes or keeping relatively still, but nevertheless alert. The only difference the scientists saw was that stimulation caused the mice to reduce their locomotive speed by about 50%. In general, this stimulation of serotonin-producing neurons did not affect other behaviors. The effect of these serotonin "peaks" on locomotion was almost instantaneous (speed reduction manifested one second after stimulation) and transient, with things going back to normal after five seconds. But during this short period of time, "the animals acted as if they weren't motivated," says Zach Mainen, who led the study.
Medicine

Genetically Modified Salmonella Destroys Cancer By Provoking An Immune Response, Study Finds (sandiegouniontribune.com) 79

schwit1 quotes a report from San Diego Union-Tribune: A genetically modified bacterium destroys tumors by provoking an immune response, according to a study published Wednesday. Using mice and cultures of human cancer cells, a South Korean-led scientific team demonstrated that Salmonella typhimurium engineered to make a foreign protein caused immune cells called macrophages and neutralizes to mobilize against the cancer. The bacterium came from an attenuated strain that has little infectious potential. Such strains have been tested as vaccines. The protein, called FlaB, is made by a gene in the estuarine bacterium Vibrio vulnificus, a close relative of the cholera bacterium, Vibrio cholerae. Tumors shrank below detectable levels in 11 out of 20 mice injected with the modified Salmonella, said the study, published in Science Translational Medicine. The engineered Salmonella provoke a sustained immune response, in addition to preventing the spread of a human colon cancer implanted in a mouse. The bacterium also were found to be nontoxic, multiplying almost exclusively inside tumors.

Slashdot Top Deals